A webcomic by Fred Gallagher, co-created by Rodney Caston, running since 2000 and also available in printed volumes.
Began as a sitcom about the misadventures of two young Americans, Piro and Largo, in a fictional version of Tokyo. Has since evolved into a multi-layered fantasy/human relations story exploring and commenting several aspects of the gaming and otaku subcultures as well as Japanese popular culture tropes such as magical girls.
