Leon Scott Kennedy is a rookie cop assigned in Raccoon Police Department (R.P.D.). In 1998, Leon would later meet Claire Redfield and arrive together in Raccoon City. Realizing the chaos brought by the outbreak, the two became separated and arrive at the city's police station to seek shelter. The two arrived at the precinct for their own purposes as they find for possible ways to escape the city as the station was also swarmed by the undead.
After the events of Raccoon City, Leon departs and was apprehended by the US military, eventually becoming a STRATCOM agent alongside with a fellow agent, Jack Krauser.
- Resident Evil 2: Leon wears a police uniform with blue shirt, blue pants, elbow pads, fingerless gloves, and black boots. In the 1998 version, Leon wears a police uniform containing shoulder pads and a body armor with the "R.P.D." logo imprinted on it. In the 2019 remake, Leon wears a more modern uniform, now containing numerous pouches and a knee pad. The R.P.D.'s patch is also imprinted on the blue shirt.
- Resident Evil 4: Leon has a brown jacket along with a black shirt, fingerless gloves, black pants, and a pair of black shoes. After losing his jacket, a holster can be seen wrapped around his torso.
- Resident Evil: The Darkside Chronicles: During the events of Operation: Javier, Leon wears a similar outfit to the ones he wore in Resident Evil 4, albeit he sports a green pants with a camouflage pattern and lacks a jacket.
- Resident Evil 6: Leon has a much more matured appearance in Resident Evil 6, he sports a black leather jacket along with black shirt, white pants, and black shoes.